So this was published on Siliconera this morning:
While Natsume handled the numbered Rune Factory games, Xseed will publish Rune Factory 4 in North America. This isn’t Xseed’s first Rune Factory title, they also released Rune Factory Frontier for Wii.
Rune Factory 4 begins when you, either a male or female character, falling from the sky unsure where they are. You are then appointed to be Selphia’s prince or princess and can manage the countryside village in the game. Rune Factory 4 has farming, cooking, and crafting quests. When you go on the field you can tame or fight monsters.
Rune Factory 4 also has a bunch of characters you can date, including some monsters that become human. Rune Factory 4 will be available this summer on Nintendo 3DS.
Apparently, it is the most popular in the series in Japan right now. Is anyone excited? I'm excited. ^_^
New info! Here's an exciting update!
UPDATE: After checking with XSEED, we received confirmation that Ys: Memories of Celceta, Valhalla Knights 3, and Rune Factory 4 (and of course Killer is Dead) will all be available as physical releases and should be up for pre-orders by this weekend on Amazon and Gamestop.